We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis.
1. Van Driessche W, Lindemann B: Quantity reliance off currents by way of solitary sodium-selective skin pores during the frog skin. Characteristics. 1979; 282 (5738): 519-520 PubMed Conceptual | Creator Complete Text
It indicates the newest good results submit by this manuscript is not justified and that i usually do not approve the manuscript in this setting
The fresh new people possess made clear several of the concerns We increased when you look at the my personal previous remark. Unfortunately, most of the big dilemmas have not been handled from this enhance. As i produced in my past review, We consider it impractical that most the individuals things is solved simply from the several added paragraphs. Rather there are particular standard issues into the fresh structure and you will, most significantly, toward analysis.
This means the fresh new solid results put forward by this manuscript try maybe not warranted and that i usually do not agree the brand new manuscript in this setting
The new authors keeps clarified a number of the questions We increased from inside the my prior comment. Unfortuitously, all big difficulties haven’t been addressed by this revision. As i stated in my earlier review, We deem they unrealistic that all those facts is going to be set just by the several additional sentences. Alternatively you may still find some fundamental questions to the experimental design and you will, very critically, into the studies.
- The very best issue is when I then followed this new breakdown away from the methods in the previous variation it actually was you are able to so you’re able to decode, having nearly primary accuracy, one arbitrary stimuli brands I chosen. Come across for examples of which reanalysis. No matter whether we imagine your actual stimulus searched within a later time or try continuously alternating between signal and you will quiet, the decoding is definitely alongside best. This might be a sign that the decryption has nothing to complete into real stimulus read from the Sender it is opportunistically exploiting some other enjoys in the analysis. The fresh manage study brand new writers performed, treating the stimuli labels, usually do not target this problem whilst is affected with equivalent condition. Essentially, precisely what the classifier try presumably using it’s time who may have introduced since recording come.
- The reason behind this is certainly presumably that people utilized low-independent data having studies and you will analysis. Assuming I understand precisely (see section step three), arbitrary sampling one half of information products regarding an enthusiastic EEG shade aren’t independent research. Repeating the research 5 times – the new handle analysis brand new experts did – isn’t a sufficient means to fix target so it matter. Randomly seeking examples of a period show containing slow alter (for instance the slow trend pastime that presumably reigns over these tracks significantly less than these circumstances) usually inevitably contain strong temporary correlations. See TemporalCorrelations.jpg set for 2D occurrence histograms and you will a correlation matrix exhibiting which.
- Since the changed actions section will bring increased detail now, it is still confused about exactly what investigation were utilized. Traditional classification analysis report exactly what studies have (typical columns from the research matrix) and you will exactly what findings (typical rows) were utilized. One thing would-be write my college essay for me a feature but normally it is the newest different EEG avenues or fMRI voxels etcetera. Findings usually are day issues. Right here I assume the brand new writers switched the newest brutal trials into a different area having fun with dominant role studies. This isn’t said if the dimensionality try reduced making use of the eigenvalues. In either case, I assume the data examples (built-up at the 128 Hz) had been then made use of because the findings and also the EEG streams switched from the PCA were utilized while the possess. The latest stimuli names have been assigned while the Into otherwise Out-of per attempt. Some 50% regarding products (and you can brands) was then chose at random to possess education, additionally the other people was applied to own assessment. So is this best?
